Open Access<p>Two-Photon Photoexcited Photodynamic Therapy with Water-Soluble Fullerenol Serving as the Highly Effective Two-Photon Photosensitizer Against Multidrug-Resistant Bacteria</p>
Author(s) -
Wen Shuo Kuo,
Chia Yuan Chang,
Jui Chang Liu,
Jian Hua Chen,
Edmund Cheung So,
Ping Wu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s236897
Subject(s) - photosensitizer , photodynamic therapy , singlet oxygen , photochemistry , quantum yield , materials science , reactive oxygen species , two photon excitation microscopy , photon , optoelectronics , chemistry , fluorescence , biophysics , oxygen , optics , biology , physics , organic chemistry , biochemistry
Multidrug-resistant (MDR) bacterial strain is a serious medical problem. Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to many antibiotics and is often associated with several diseases such as arthritis, osteomyelitis, and endocarditis. The development of an alternative treatment for eliminating MDR bacteria such as MRSA has attracted a considerable amount of research attention. Moreover, the development of a material for highly efficient generation of reactive oxygen species (ROS) involving two-photon photodynamic therapy (PDT) is currently desirable.