Open Access<p>Encapsulated <em>n</em>-Butylidenephthalide Efficiently Crosses the Blood–Brain Barrier and Suppresses Growth of Glioblastoma</p>
Author(s) -
Yuling Lin,
Xiao Fan Huang,
KaiFu Chang,
Kuang Wen Liao,
NuMan Tsai
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s235815
Subject(s) - in vivo , cancer research , apoptosis , cell cycle , cell cycle checkpoint , medicine , chemistry , biology , biochemistry , microbiology and biotechnology
n- Butylidenephthalide (BP) has anti-tumor effects on glioblastoma. However, the limitation of BP for clinical application is its unstable structure. A polycationic liposomal polyethylenimine (PEI) and polyethylene glycol (PEG) complex (LPPC) has been developed to encapsulate BP for drug structure protection. The purpose of this study was to investigate the anti-cancer effects of the BP/LPPC complex on glioblastoma in vitro and in vivo.