Open Access<p>Effect of Graphene Oxide and Silver Nanoparticles Hybrid Composite on P. aeruginosa Strains with Acquired Resistance Genes</p>
Author(s) -
Povilas Lozovskis,
Virginija Jankauskaitė,
Asta Guobienė,
Violeta Kareivienė,
Astra Vitkauskienė
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s235748
Subject(s) - polyvinylpyrrolidone , pseudomonas aeruginosa , nanocomposite , graphene , antibiotic resistance , silver nanoparticle , fourier transform infrared spectroscopy , materials science , nanoparticle , x ray photoelectron spectroscopy , antibiotics , antimicrobial , oxide , biofilm , surface modification , microbiology and biotechnology , nuclear chemistry , chemistry , chemical engineering , bacteria , nanotechnology , biology , polymer chemistry , metallurgy , engineering , genetics
In the last decades, nosocomial infections caused by drug-resistant Pseudomonas aeruginosa became a common problem in healthcare facilities. Antibiotics are becoming less effective as new resistant strains appear. Therefore, the development of novel enhanced activity antibacterial agents becomes very significant. A combination of nanomaterials with different physical and chemical properties enables us to generate novel multi-functional derivatives. In this study, graphene oxide and polyvinylpyrrolidone-stabilized silver nanoparticles hybrid nanocomposite (GO-Ag HN) were synthesized. The relation between antibiotic resistance and GO-Ag HN potential toxicity to clinical P. aeruginosa strains, their antibiotic resistance, and molecular mechanisms were assessed.