Open Access<p>Electrosprayed Polymeric Nanospheres for Enhanced Solubility, Dissolution Rate, Oral Bioavailability and Antihyperlipidemic Activity of Bezafibrate</p>
Author(s) -
Runbin Sun,
Chengwu Shen,
Shumaila Shafique,
Omer Mustapha,
Talib Hussain,
Ikram Ullah Khan,
Yasir Mehmood,
Khaleeq Anwer,
Yasser Shahzad,
Abid Mehmood Yousaf
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s235146
Subject(s) - bioavailability , bezafibrate , solubility , differential scanning calorimetry , dissolution , fourier transform infrared spectroscopy , materials science , chemistry , chromatography , nuclear chemistry , pharmacology , chemical engineering , organic chemistry , medicine , biochemistry , physics , engineering , thermodynamics
Bezafibrate is a BCS class II drug as it presents very low solubility in water; therefore, its bioavailability after oral administration is very poor. The aim of this work was to enhance solubility and dissolution rate of bezafibrate in water in order to enhance its oral bioavailability.