Open Access<p>VEGF-Modified PVA/Silicone Nanofibers Enhance Islet Function Transplanted in Subcutaneous Site Followed by Device-Less Procedure</p>
Author(s) -
Bin Yang,
Guodong Cao,
Kailun Cai,
Gang Wang,
Pengping Li,
Lei Zheng,
Haolei Cai,
Zhu Yang,
Xiang Li,
Yulian Wu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s232224
Subject(s) - islet , transplantation , vascular endothelial growth factor , silicone , nanofiber , in vivo , chemistry , medicine , insulin , biology , materials science , vegf receptors , nanotechnology , microbiology and biotechnology , organic chemistry
As heterologous islets or islet-like stem cells become optional sources for islet transplantation, the subcutaneous site appears to be an acceptable replacement of the intrahepatic site due to its graft retrievability. The device-less (DL) procedure improves the feasibility; however, some limitations such as fibrotic overgrowth or immunodeficiency still exist. Nanofibers could mimic the extracellular matrix to improve the vitality of transplanted islets. Therefore, we designed a vascular endothelial growth factor (VEGF)-modified polyvinyl alcohol (PVA)/silicone nanofiber (SiO2-VEGF) to optimize the DL procedure.