Open Access<p>Regulation of ERK1/2 and SMAD2/3 Pathways by Using Multi-Layered Electrospun PCL–Amnion Nanofibrous Membranes for the Prevention of Post-Surgical Tendon Adhesion</p>
Author(s) -
Chunjie Liu,
Siyu Tian,
Jing Bai,
Kaijiang Yu,
Lei Liu,
Guoli Li,
Ruiyi Dong,
Dehu Tian
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s231538
Subject(s) - tendon , adhesion , materials science , amnion , membrane , electrospinning , biomedical engineering , ultimate tensile strength , chemistry , anatomy , medicine , composite material , biology , biochemistry , pregnancy , fetus , genetics , polymer
Adhesion after tendon injury is a common complication in clinical practice. The lack of effective prevention mechanisms seriously affects the functional rehabilitation of patients. This research aimed to optimise the amniotic membrane and explain the mechanism of tendon-amniotic membrane by imitating the tendon sheath to construct a multilayer electrospun polycaprolactone (PCL) nanofibre membrane.