Open Access<p>Antitumor Activity of Thermosensitive Hydrogels Packaging Gambogic Acid Nanoparticles and Tumor-Penetrating Peptide iRGD Against Gastric Cancer</p>
Author(s) -
Dinghu Zhang,
YingHao Chu,
Qian Hu,
Lingyu Qian,
Jie Shao,
Qiuping Xu,
Lan Yu,
Rutian Li,
Quanan Zhang,
Fenglei Wu,
Baorui Liu,
Qin Liu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s231448
Subject(s) - self healing hydrogels , gambogic acid , in vivo , chemistry , biophysics , nanoparticle , materials science , nuclear chemistry , biochemistry , nanotechnology , in vitro , polymer chemistry , microbiology and biotechnology , biology
Gambogic acid (GA) is proved to have anti-tumor effects on gastric cancer. Due to poor solubility, non-specific biological distribution, toxicity to normal tissues and short half-life, it is hard to be applied into the clinic. To overcome these issues, we developed a thermosensitive and injectable hydrogel composed of hydroxypropyl cellulose, silk fibroin and glycerol, with short gelling time, good compatibility and sustained release, and demonstrated that the hydrogel packaged with gambogic acid nanoparticles (GA-NPs) and tumor-penetrating peptide iRGD could improve the anti-tumor activity.