Open Access<p>Cationic <em>Antheraea pernyi</em> Silk Fibroin-Modified Adenovirus-Mediated ING4 and IL-24 Dual Gene Coexpression Vector Suppresses the Growth of Hepatoma Carcinoma Cells</p>
Author(s) -
Jing Qu,
Weiwei Wang,
Yanfei Feng,
Longxing Niu,
Mingzhong Li,
Jicheng Yang,
Yongdun Xie
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s230693
Subject(s) - genetic enhancement , fibroin , microbiology and biotechnology , biology , cancer research , gene delivery , viral vector , chemistry , gene , biochemistry , materials science , silk , recombinant dna , composite material
Cancer gene therapy requires both effective tumor suppressor genes and safe vectors that express target genes efficiently. Inhibitor of growth 4 (ING4) inhibits tumor growth via multiple pathways. Interleukin-24 (IL-24) also has tumor-suppressive activity against a broad spectrum of human cancers. Adenovirus (Ad) vectors exhibit high infection efficiency, but potential toxicity related to high doses of adenovirus has led to careful reconsideration of their use in human clinical trials. Antheraea pernyi silk fibroin (ASF) is a cytocompatible and biodegradable natural polymer, and it possesses Arg-Gly-Asp sequences exhibiting a high binding affinity and selectivity for α v β 3 and α v β 5 integrin receptors, which are overexpressed in tumor vessels and most tumor cells.