Open Access<p>A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy</p>
Author(s) -
Zhanghua Chen,
Rijin Song,
Pei Hsuan Lu,
Shiguo Chen,
Yufan Zhou,
Gang Shen,
Minjun Jiang,
Wei Zhang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s230237
Subject(s) - prodrug , reactive oxygen species , drug delivery , cancer cell , intracellular , drug , cancer , mitochondrial ros , chemistry , cancer research , pharmacology , biophysics , biochemistry , medicine , biology , organic chemistry
Poor cell uptake and incomplete intracellular drug release are the two major challenges for polymeric prodrug-based drug delivery systems (PPDDSs) in cancer treatment.