Open Access<p>A Novel Drug Delivery Carrier Comprised of Nimodipine Drug Solution and a Nanoemulsion: Preparation, Characterization, in vitro, and in vivo Studies</p>
Author(s) -
Saixu Huang,
Zhiyong Huang,
Zhiqin Fu,
Yamin Shi,
Qi Dai,
Shuyan Tang,
Yongwei Gu,
Yue Xu,
Jianming Chen,
Xin Wu,
Fuzheng Ren
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s226591
Subject(s) - nimodipine , hemolysis , in vivo , irritation , pharmacokinetics , pharmacology , medicine , materials science , calcium , microbiology and biotechnology , immunology , biology
Nimodipine (NIMO) is used clinically to treat ischemic damage resulting from subarachnoid hemorrhage. However, clinical application of NIMO is limited by poor aqueous solubility and low safety. To overcome these limitations, a novel two-vial NIMO-loaded nanoemulsion (NIMO-TNE) was designed in this study.