Open Access<p>Electrospun Poly (Aspartic Acid)-Modified Zein Nanofibers for Promoting Bone Regeneration</p>
Author(s) -
Yun Liu,
Yingling Miao,
Feng Qin,
Cen Cao,
Xiaolin Yu,
Yuhan Wu,
Tianlu Wang,
Ruogu Xu,
Liang Zhao,
Fan Wu,
Zhengchuan Zhang,
Junhua Yang,
Yang Yang,
Xin Xie,
Liming Zhang,
Feilong Deng
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s224265
Subject(s) - nanofiber , staining , in vivo , regeneration (biology) , stromal cell , chemistry , cell growth , electrospinning , materials science , biophysics , biochemistry , microbiology and biotechnology , nanotechnology , biology , pathology , medicine , polymer , organic chemistry
Critical-sized bone defects raise great challenges. Zein is of interest for bone regeneration, but it has limited ability to stimulate cell proliferation. In this regard, a poly (aspartic acid) (PAsp)-zein hybrid is promising, as PAsp can promote rat bone marrow stromal cell (rBMSCs) proliferation and osteogenic differentiation. This research aimed to develop electrospun PAsp-modified zein nanofibers to realize critical-sized bone defects repair.