Open Access<p>cRGD-Conjugated Fe<sub>3</sub>O<sub>4</sub>@PDA-DOX Multifunctional Nanocomposites for MRI and Antitumor Chemo-Photothermal Therapy</p>
Author(s) -
Xiaolong Fan,
Zeting Yuan,
Chenting Shou,
Guohua Fan,
Hong Wang,
Feng Gao,
Yuanpeng Rui,
Ke Xu,
Peihao Yin
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s222797
Subject(s) - photothermal therapy , nanocarriers , in vivo , doxorubicin , cytotoxicity , confocal microscopy , zeta potential , biophysics , cancer research , drug delivery , materials science , internalization , in vitro , conjugated system , photothermal effect , chemistry , nanoparticle , nanotechnology , cell , chemotherapy , medicine , biochemistry , microbiology and biotechnology , biology , surgery , composite material , polymer
Photothermal therapy (PTT) has great potential in the clinical treatment of tumors. However, most photothermal materials are difficult to apply due to their insufficient photothermal conversion efficiencies (PCEs), poor photostabilities and short circulation times. Furthermore, tumor recurrence is likely to occur using PTT only. In the present study, we prepared cyclo (Arg-Gly-Asp-d-Phe-Cys) [c(RGD)] conjugated doxorubicin (DOX)-loaded Fe 3 O 4 @polydopamine (PDA) nanoparticles to develop a multifunctional-targeted nanocomplex for integrated tumor diagnosis and treatment.