Open Access<p>Nitroxide-Modified Protein-Incorporated Nanoflowers with Dual Enzyme-Like Activities</p>
Author(s) -
Zhuofu Wu,
Sitong Zhang,
Xiaojun Wang,
Can Cai,
Guang Chen,
Li Ma
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s220718
Subject(s) - catalase , electron paramagnetic resonance , fourier transform infrared spectroscopy , superoxide dismutase , chemistry , nuclear chemistry , biophysics , materials science , combinatorial chemistry , enzyme , chemical engineering , biochemistry , biology , nuclear magnetic resonance , physics , engineering
Combined superoxide dismutase (SOD)/catalase mimetics have attracted much attention because of their efficacy against reactive oxygen species-associated diseases; however, their application is often limited owing to their poor stability and the absence of favorable grafting sites. To address this, we developed a new class of SOD/catalase mimetics based on hybrid nanoflowers, which exhibit superior stability and possess the desired grafting sites for drugs and endogenous molecules.