Open Access<p>Synthesis Of PEG-Coated, Ultrasmall, Manganese-Doped Iron Oxide Nanoparticles With High Relaxivity For T<sub>1</sub>/T<sub>2</sub> Dual-Contrast Magnetic Resonance Imaging</p>
Author(s) -
Shilin Xiao,
Lei Yu,
Liang Zhang,
Ya Zhang,
Weijie Fan,
Tao Sun,
Chunyu Zhou,
Yun Liu,
Yiding Liu,
Mingfu Gong,
Dong Zhang
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s219749
Subject(s) - materials science , manganese , nanoparticle , manganese oxide , peg ratio , doping , nuclear chemistry , nanotechnology , chemical engineering , chemistry , metallurgy , optoelectronics , engineering , finance , economics
Beyond magnetic resonance imaging (MRI), which has been widely used clinically, molecular MRI (mMRI) can further provide qualitative and quantitative information at the cellular and molecular levels. However, the diagnostic accuracy may not be satisfactory via single-contrast mMRI due to some interferences in vivo. T 1 /T 2 dual-contrast MRI using the same contrast agent (CA) could significantly improve the detection accuracy. Therefore, in this study, we fabricated poly(ethylene glycol) (PEG)-coated, manganese-doped iron oxide nanocomposites (Mn-IONPs@PEG) as T 1 /T 2 dual-contrast CA, and evaluated its feasibility of T 1 /T 2 dual-contrast MRI in vitro and in vivo.