Open Access<p>The In Vitro Immunomodulatory Effects Of Gold Nanoparticles Synthesized From <em>Hypoxis hemerocallidea</em> Aqueous Extract And Hypoxoside On Macrophage And Natural Killer Cells</p>
Author(s) -
Abdulrahman M. Elbagory,
Ahmed A. Hussein,
Mervin Meyer
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s216972
Subject(s) - immune system , cytokine , in vitro , macrophage , pharmacology , chemistry , immunology , medicine , biochemistry
Macrophages and Natural Killer (NK) cells are an integral part of the innate immune system. These cells produce pro-inflammatory cytokines in response to bacterial infections. However, prolonged inflammation can be a contributing factor in the etiology of several diseases such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, psoriasis and eczema. Reducing the secretion of pro-inflammatory cytokines is an effective treatment strategy for these conditions. Gold nanoparticles (AuNPs) have been shown to have immunosuppressive effects. Extracts of the Hypoxis hemerocallidea plant have also been shown to have immunomodulatory effects. It has been demonstrated previously that extracts of the H. hemerocallidea can be used to synthesize AuNPs.