Open Access<p>Synthesis of Silver Nanoparticle Employing Corn Cob Xylan as a Reducing Agent with Anti-<em>Trypanosoma cruzi</em> Activity</p>
Author(s) -
Talita K. B. Pinto,
Rony Lucas Silva Viana,
Cláudia Jassica Gonçalves Moreno,
Jefferson da Silva Barbosa,
Francimar Lopes de Sousa Júnior,
Mayara Jane Campos de Medeiros,
Raniere Fagundes Melo-Silveira,
Jailma Almeida-Lima,
Daniel de Lima Pontes,
Marcelo S. Silva,
Hugo Alexandre Oliveira Rocha
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s216386
Subject(s) - nuclear chemistry , dynamic light scattering , silver nanoparticle , spectroscopy , raman spectroscopy , trypanosoma cruzi , materials science , mtt assay , fourier transform infrared spectroscopy , nanoparticle , chemistry , nanotechnology , chemical engineering , biochemistry , parasite hosting , physics , engineering , quantum mechanics , world wide web , computer science , optics , cell
Chagas disease, also known as American Trypanosomiasis, is caused by the protozoan Trypanosoma cruzi . It is occurring in Americas, including USA and Canada, and Europe and its current treatment involves the use of two drugs as follows: benznidazole (BNZ) and nifurtimox, which present high toxicity and low efficacy during the chronic phase of the disease, thus promoting the search for more effective therapeutic alternatives. Amongst them xylan, a bioactive polysaccharide, extracted from corn cob.