Open Access<p>Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles</p>
Author(s) -
Catarina RomaRodrigues,
Alexandra R. Fernandes,
Pedro V. Baptista
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s215711
Subject(s) - colloidal gold , microvesicles , cancer research , leukemia , medicine , pharmacology , nanoparticle , nanotechnology , chemistry , materials science , microrna , biochemistry , gene
Progression of chronic myeloid leukemia (CML) is frequently associated with increased angiogenesis at the bone marrow mediated by exosomes. The capability of gold nanoparticles (AuNPs) functionalized with antiangiogenic peptides to hinder the formation of new blood vessels has been demonstrated in a chorioallantoic membrane (CAM) model.