Open Access<p>Combined Therapeutic Effects of <sup>131</sup>I-Labeled and 5Fu-Loaded Multifunctional Nanoparticles in Colorectal Cancer</p>
Author(s) -
Pingping Wu,
Huayun Zhu,
Yan Zhuang,
Xiaofeng Sun,
Ning Gu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s215137
Subject(s) - peg ratio , ethylene glycol , apoptosis , cancer research , flow cytometry , colorectal cancer , drug delivery , viability assay , chemistry , pharmacology , materials science , medicine , cancer , nanotechnology , biochemistry , immunology , organic chemistry , finance , economics
Owing to its combined effects, the co-delivery of different therapeutics is a promising option for the treatment of cancer. In the present study, tumor-targeting poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) nanoparticles were developed for the transportation of two molecules, namely chemotherapeutic drug 5-fluorouracil (5Fu) and radionuclide iodine-131 ( 131 I), in a single platform.