Open Access<p>The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via Intranasal Route</p>
Author(s) -
Yongming Jiang,
Chenqi Liu,
Wei Zhai,
Ning Zhuang,
Tong Han,
Zhiying Ding
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s214657
Subject(s) - pharmacology , nasal administration , zeta potential , blood–brain barrier , isopropyl myristate , chemistry , lactoferrin , materials science , medicine , chromatography , biochemistry , nanotechnology , nanoparticle , central nervous system
Huperzine A (HupA) is a selective acetylcholinesterase inhibitor used to treat Alzheimer's disease. The existing dosage of HupA lacks brain selectivity and can cause serious side effects in the gastrointestinal and peripheral cholinergic systems.