Open Access<p>Development of Nanosome-Encapsulated Honokiol for Intravenous Therapy Against Experimental Autoimmune Encephalomyelitis</p>
Author(s) -
Yai Ping Hsiao,
Hui Ting Chen,
Yu Chih Liang,
Tse-En Wang,
Kai Hung Huang,
Cheng-Chih Hsu,
Hong Liang,
Chun-Ta Huang,
Tong-Rong Jan
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s214349
Subject(s) - experimental autoimmune encephalomyelitis , medicine , multiple sclerosis , honokiol , spinal cord , pharmacology , encephalomyelitis , neuroprotection , inflammation , systemic administration , microglia , immunology , in vivo , microbiology and biotechnology , psychiatry , biology
Honokiol has been reported to possess anti-inflammatory and neuroprotective activities. However, the poor aqueous solubility of honokiol limits its clinical application for systemic administration.