Open Access<p>Rifampicin-Carbohydrate Spray-Dried Nanocomposite: A Futuristic Multiparticulate Platform For Pulmonary Delivery</p>
Author(s) -
Mohammed M. Mehanna,
Salma M. Mohyeldin,
Nazik A. Elgindy
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s211182
Subject(s) - maltodextrin , spray drying , bioavailability , materials science , nanocomposite , inhalation , differential scanning calorimetry , mannitol , pharmacology , chromatography , chemistry , medicine , nanotechnology , organic chemistry , anatomy , thermodynamics , physics
Rifampicin, a first-line anti-tuberculosis drug, was loaded into a carbohydrate-based spray-dried nanocomposite with the aim to design a dry powder inhalation formulation. This strategy can enable efficient distribution of rifampicin within the lungs, localizing its action, enhancing its bioavailability and reducing its systemic exposure consequently side effects.