Open Access<p>Mechano-signalling, induced by fullerene C<sub>60</sub> nanofilms, arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells</p>
Author(s) -
Malwina Sosnowska,
Marta Kutwin,
Sławomir Jaworski,
Barbara Strojny,
Mateusz Wierzbicki,
Jarosław Szczepaniak,
Maciej Łojkowski,
Wojciech Święszkowski,
Jaśmina Bałaban,
A. Chwalibog,
Ewa Sawosz
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s206934
Subject(s) - flow cytometry , extracellular matrix , cell growth , biophysics , cell , cell cycle , apoptosis , nanotechnology , microbiology and biotechnology , cancer cell , materials science , nanotopography , chemistry , biology , biochemistry , cancer , genetics
Degradation of the extracellular matrix (ECM) changes the physicochemical properties and dysregulates ECM-cell interactions, leading to several pathological conditions, such as invasive cancer. Carbon nanofilm, as a biocompatible and easy to functionalize material, could be used to mimic ECM structures, changing cancer cell behavior to perform like normal cells.