Open Access<p>A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine</p>
Author(s) -
Xuan Li,
Ziying Yang,
Jiacheng Sun,
Teng Ma,
Fei Hua,
Zhenya Shen
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s205574
Subject(s) - mesenchymal stem cell , regenerative medicine , stem cell , biodistribution , in vivo , nanotechnology , medicine , biology , materials science , microbiology and biotechnology
Multipotent mesenchymal stem cells have shown great promise for application in regenerative medicine owing to their particular therapeutic effects, such as significant self-renewability, low immunogenicity, and ability to differentiate into a variety of specialized cells. However, there remain certain complicated and unavoidable problems that limit their further development and application. One of the challenges is to noninvasively monitor the delivery and biodistribution of transplanted stem cells during treatment without relying on behavioral endpoints or tissue histology, and it is important to explore the potential mechanisms to clarify how stem cells work in vivo. To solve these problems, various nanoparticles (NPs) and their corresponding imaging methods have been developed recently and have made great progress. In this review, we mainly discuss NPs used to label stem cells and their toxic effects on the latter, the imaging techniques to detect such NPs, and the current existing challenges in this field.