Open Access<p>Synthesis, characterization, and mechanistic studies of a gold nanoparticle–amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity</p>
Author(s) -
Prakash Kumar,
Pushkar Shivam,
Saptarshi Mandal,
Pragya Prasanna,
Saurabh Kumar,
Surendra Rajit Prasad,
Ashish Kumar,
Prolay Das,
Vahab Ali,
Shubhankar Kumar Singh,
Debabrata Mandal
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s196421
Subject(s) - conjugate , cytotoxicity , covalent bond , amphotericin b , chemistry , nuclear chemistry , carbodiimide , biochemistry , biology , organic chemistry , in vitro , microbiology and biotechnology , antifungal , mathematical analysis , mathematics
Amphotericin B (AmB) as a liposomal formulation of AmBisome is the first line of treatment for the disease, visceral leishmaniasis, caused by the parasite Leishmania donovani . However, nephrotoxicity is very common due to poor water solubility and aggregation of AmB. This study aimed to develop a water-soluble covalent conjugate of gold nanoparticle (GNP) with AmB for improved antileishmanial efficacy and reduced cytotoxicity.