Open Access<p>Targeted lipid nanoparticle delivery of calcitriol to human monocyte-derived macrophages in vitro and in vivo: investigation of the anti-inflammatory effects of calcitriol</p>
Author(s) -
Aisha Rafique,
Anders Etzerodt,
Jonas Heilskov Graversen,
Søren K. Moestrup,
Frederik DagnæsHansen,
Holger Jon Møller
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s192113
Subject(s) - calcitriol , in vivo , in vitro , cytokine , monocyte , pharmacology , calcitriol receptor , tumor necrosis factor alpha , inflammation , chemistry , medicine , receptor , immunology , biology , biochemistry , vitamin d and neurology , microbiology and biotechnology
Vitamin D 3 possesses anti-inflammatory and modulatory properties in addition to its role in calcium and phosphate homeostasis. Upon activation, macrophages (M) can initiate and sustain pro-inflammatory cytokine production in inflammatory disorders and play a pathogenic role in certain cancers.