Open Access<p>Osteochondral repair using scaffolds with gradient pore sizes constructed with silk fibroin, chitosan, and nano-hydroxyapatite</p>
Author(s) -
Hongli Xiao,
WenLiang Huang,
Kun Xiong,
Shiqiang Ruan,
Yuan Cheng,
Gang Mo,
Tian Ren-yuan,
Sirui Zhou,
Rongfeng She,
Ye Peng,
Bin Liu,
Jing Deng
Publication year - 2019
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s191627
Subject(s) - fibroin , chitosan , materials science , silk , nano , composite material , chemical engineering , biomedical engineering , medicine , engineering
One of the main problems associated with the development of osteochondral reparative materials is that the accurate imitation of the structure of the natural osteochondral tissue and fabrication of a suitable scaffold material for osteochondral repair are difficult. The long-term outcomes of single- or bilayered scaffolds are often unsatisfactory because of the absence of a progressive osteochondral structure. Therefore, only scaffolds with gradient pore sizes are suitable for osteochondral repair to achieve better proliferation and differentiation of the stem cells into osteochondral tissues to complete the repair of defects.