Open AccessThe role of the ERK1/2 pathway in simvastatin-loaded nanomicelles and simvastatin in regulating the osteogenic effect in MG63 cells
Author(s) -
Mao Niu,
Xiaoshan Feng,
Lei Zhou
Publication year - 2018
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s182998
Subject(s) - simvastatin , western blot , chemistry , pharmacology , drug , signal transduction , drug delivery , microbiology and biotechnology , medicine , biochemistry , biology , gene , organic chemistry
The present study aimed to clarify the role of the ERK1/2 pathway in simvastatin (SV)-loaded nanomicelles (SVNs)- and SV-mediated promotion of cell osteogenic differentiation and explore the molecular mechanisms by which SVNs exhibited a greater efficacy in promoting osteogenic differentiation than SV.