Open AccesspH-responsive hybrid nanoparticle with enhanced dissociation characteristic for siRNA delivery
Author(s) -
Menghao Shi,
Xiufeng Zhao,
Jiulong Zhang,
Shengli Pan,
Chunrong Yang,
Ying Wei,
Haiyang Hu,
Mingxin Qiao,
Fan Chen
Publication year - 2018
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s180119
Subject(s) - gene silencing , ethylene glycol , apoptosis , in vivo , chemistry , small interfering rna , rna interference , cancer research , nanoparticle , transfection , biophysics , microbiology and biotechnology , materials science , biochemistry , nanotechnology , biology , rna , gene , organic chemistry
Specific polo-like kinase (PLK1) silencing with small interface RNA (siRNA) may be an effective approach for PLK1-overexpressed lung cancer. However, low siRNA concentration into cytoplasm of tumor tissue severely limits its application.