Open AccessDyspepsia-Like Symptoms in Helicobacter pylori-Negative Chronic Gastritis are Associated with ASCA-, ANCA-, and Celiac Seropositivity but Not with Other Autoimmune Parameters: A Single-Centre, Retrospective Cross-Sectional Study
Author(s) -
Noémi Zádori,
Dávid Németh,
Levente Frim,
Nóra Vörhendi,
Lajos Szakó,
Szilárd Váncsa,
Péter Hegyi,
József Czimmer
Publication year - 2022
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s380419
Subject(s) - medicine , helicobacter pylori , gastroenterology , serology , gastritis , etiology , autoimmune gastritis , atrophic gastritis , gerd , immunology , population , chronic gastritis , intestinal metaplasia , disease , antibody , reflux , environmental health
Dyspeptic symptoms are frequent in the general population, with a high socioeconomic burden. Helicobacter pylori ( H. pylori ) might be a possible etiological factor; however, it is also common in H. pylori negative gastritis. Clarification of the underlying aetiology might be beneficial to set up the optimal treatment strategy for dyspepsia and chronic gastritis (CG) itself. We aimed to assess the prevalence of dyspeptic symptoms in patients with H. pylori negative CG and explore autoimmunity's possible role.