Open AccessAn Integrative Transcriptomic Analysis Reveals EGFR Exon-19 E746-A750 Fragment Deletion Regulated miRNA, circRNA, mRNA and lncRNA Networks in Lung Carcinoma
Author(s) -
Ling Chen,
Shenyi Li,
Weifeng Shi,
Yibo Wu
Publication year - 2022
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s370247
Subject(s) - microrna , exon , medicine , transcriptome , messenger rna , computational biology , cancer research , adenocarcinoma , bioinformatics , gene , genetics , cancer , biology , gene expression
Competing endogenous RNA (ceRNA) appears to be an important post-transcriptional manner that regulates gene expression through a miRNA-mediated mechanism. Mutations in exon-19 of EGFR were frequently observed in lung cancer genes, which were associated with EGFR activity and EGFR-targeted therapies.