Open AccessLactate Transporter SLC16A3 (MCT4) as an Onco-Immunological Biomarker Associating Tumor Microenvironment and Immune Responses in Lung Cancer
Author(s) -
Qingsong Tao,
Xin Li,
Ting Zhu,
Xun Ge,
Shipeng Gong,
Jianxin Guo,
Ruishuang Ma
Publication year - 2022
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s353592
Subject(s) - immune system , tumor microenvironment , immune checkpoint , cancer research , medicine , foxp3 , adenocarcinoma , immunotherapy , lung cancer , immunology , cancer , oncology
Lactate, a marker of tumor metabolic reprogramming, maintains the acidic microenvironment and also affects the metabolism and function of immune cells. SLC16A3 is responsible for the extracellular transport of lactate, which is a key component of glycolysis. However, the role of SLC16A3 in immune infiltration and immunosuppression of lung cancer is largely unknown. Our study explored the therapeutic and prognostic value of SLC16A3 in predicting immune infiltration and immune checkpoint efficacy of lung cancer.