Open AccessRelationships Among Gut Microbiota, Ischemic Stroke and Its Risk Factors: Based on Research Evidence
Author(s) -
Qinhong Huang,
Guannan Cai,
Ting Liu,
Zhihua Liu
Publication year - 2022
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s353276
Subject(s) - medicine , stroke (engine) , gut flora , dysbiosis , ischemic stroke , diabetes mellitus , disease , inflammation , obesity , bioinformatics , immunology , intensive care medicine , ischemia , endocrinology , biology , mechanical engineering , engineering
Stroke is a highly lethal disease and disabling illness while ischemic stroke accounts for the majority of stroke. It has been found that inflammation plays a key role in the initiation and progression of stroke, and atherosclerotic plaque rupture is considered to be the leading cause of ischemic stroke. Furthermore, chronic inflammatory diseases, such as obesity, type 2 diabetes mellitus (T2DM) and hypertension, are also considered as the high-risk factors for stroke. Recently, the topic on how gut microbiota affects human health has aroused great concern. The initiation and progression of ischemic stroke has been found to have close relation with gut microbiota dysbiosis. Hence, this manuscript briefly summarizes the roles of gut microbiota in ischemic stroke and its related risk factors, and the practicability of preventing and alleviating ischemic stroke by reconstructing gut microbiota.