Open AccessIdentifying Molecular Subtypes and 6-Gene Prognostic Signature Based on Hypoxia for Optimizing Targeted Therapies in Non-Small Cell Lung Cancer
Author(s) -
Jingrong Lin,
Shujiao Chen,
Linling Xiao,
Ziyan Wang,
Yanqing Lin,
Shungui Xu
Publication year - 2022
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s352238
Subject(s) - lung cancer , medicine , hypoxia (environmental) , gene signature , gene , oncology , immunotherapy , tumor microenvironment , cancer research , cancer , bioinformatics , biology , gene expression , genetics , chemistry , organic chemistry , oxygen
Non-small cell lung cancer (NSCLC) accounts for a great number of all lung cancer cases. Hypoxia, one of the hallmarks in solid cancer, is closely involved in cancer cell progression and migration. This study aimed to develop a molecular subtyping system based on hypoxia-related genes and construct a prognostic model for NSCLC patients.