Open AccessAnalysis of Gene Co-Expression Network to Identify the Role of CD8 + T Cell Infiltration-Related Biomarkers in High-Grade Glioma
Author(s) -
Peng Feng,
Yuchen Li,
Zhijie Tian,
Yuan Qian,
Xingyu Miao,
Yuelin Zhang
Publication year - 2022
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s348470
Subject(s) - glioma , cd8 , gene , gene expression , gene expression profiling , cancer research , glioblastoma , immune system , genome , biology , medicine , computational biology , genetics
High-grade glioma is a type of heterogeneous lethal brain tumor most common in adults. At present, immune checkpoint inhibitors (ICIs) are being considered for first-line therapeutics for malignant GBM. Nonetheless, molecular markers for malignant GBM are unavailable at present. As a result, it is important to explore molecular markers related to immunity for GBM.