Open AccessDown-Regulation of Activating Transcription Factor 3 (ATF3) in Hepatoblastoma and Its Relationship with Ferroptosis
Author(s) -
Jing-Xiao Li,
JinShu Pang,
Bin-Tong Yin,
Gang Chen,
Junhong Chen,
JiaYuan Luo,
Yang Xia,
Li-Ting Qin,
JiangHui Zeng,
Peng Chen,
Jiabo Chen,
Deng Tang
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s340939
Subject(s) - atf3 , activating transcription factor , transcription factor , chromatin immunoprecipitation , gene , hepatoblastoma , microarray , biology , transcriptional regulation , medicine , gene expression , genetics , promoter
The molecular mechanisms and signal pathways of ferroptosis in hepatoblastoma (HB) have not yet been clarified. In previous studies, activating transcription factor 3 (ATF3) was reported to be correlated with several tumors, but the clinical significance of ATF3 has never been determined. Herein, we investigated the clinicopathological value and mechanisms of ATF3 in regulating ferroptosis in HB.