Open AccessAge- and Gender-Independent Association of XRCC1 Arg399Gln Polymorphism with Chronic Myeloid Leukemia
Author(s) -
Ezeldine K Abdalhabib,
Denise E. Jackson,
Badr Alzahrani,
Elyasa Mustafa Elfaki,
Alneil Hamza,
Abdelbaset Mohamed Elasbali,
Fehaid Alanazi,
Abdulrahman Algarni,
Ibrahim Khider Ibrahim,
Muhammad Saboor
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s340283
Subject(s) - myeloid leukemia , genotype , xrcc1 , medicine , restriction fragment length polymorphism , allele , gastroenterology , leukemia , immunology , genetics , gene , biology , single nucleotide polymorphism
DNA damage to hematopoietic progenitor cells is an essential factor for leukemia development as a failure of the host DNA repair system to fix errors in DNA. This study aimed to assess the association of XRCC1 gene polymorphisms including Arg194Trp, Arg399Gln, and Arg280His with the risk of development of CML in Sudanese population.