Open AccessZWINT is a Promising Therapeutic Biomarker Associated with the Immune Microenvironment of Hepatocellular Carcinoma
Author(s) -
Tong Lin,
Yingzhao Zhang,
Lin Zheng,
Lisheng Peng
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s340057
Subject(s) - hepatocellular carcinoma , downregulation and upregulation , medicine , cancer research , kegg , immune checkpoint , cell cycle , gene , biology , immune system , immunology , genetics , gene expression , transcriptome , immunotherapy
The prognosis of patients with advanced hepatocellular carcinoma (HCC) is still poor, effective therapeutic targets are needed. ZW10 interacting kinetochore protein (Zwint) is an essential component of the mitotic spindle checkpoint and is upregulated in cancers. Disappointing, the role of ZWINT in HCC has not been fully illuminated.