Open AccessGene Co-Expression Analysis Identified Preserved and Survival-Related Modules in Severe Blunt Trauma, Burns, Sepsis, and Systemic Inflammatory Response Syndrome
Author(s) -
Jingrui Huo,
Lei Wang,
Yi Tian,
Wenjie Sun,
Guoan Zhang,
Yan Zhang,
Ying Li,
Jingjing Zhang,
Xiaohui Yang,
Yingfu Liu
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s336785
Subject(s) - sepsis , medicine , systemic inflammatory response syndrome , transcriptome , blunt trauma , immunology , gene , gene expression , bioinformatics , biology , genetics , surgery
Severe trauma and burns accompanied by sepsis are associated with high morbidity and mortality. Little is known about the transcriptional similarity between trauma, burns, sepsis, and systemic inflammatory response syndrome (SIRS). Uncovering key genes and molecular networks is critical to understanding the biology of disease. Conventional analysis of gene changes (fold change) analysis is difficult for time-serial data such as post-injury blood transcriptome.