Open AccessIntegrated Analysis of Mutations, miRNA and mRNA Expression in Glioblastoma
Author(s) -
Shichao Wang,
Huanmin Zhou,
RuiJian Zhang,
YanRu Zhang
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s336421
Subject(s) - microrna , glioma , transcriptome , tumor progression , cancer research , gene , biology , medicine , biological pathway , gene expression , oncogene , cancer , disease , bioinformatics , genetics , cell cycle , pathology
Glioblastoma multiforme (GBM) is a common, malignant brain tumor in adults, with a median survival of only 15-23 months. Organisms respond to disease stress through sophisticated mechanisms at the physiological, transcriptional and metabolic levels. However, the molecular regulatory networks responsible for occurrence, progression and recurrence of glioma have yet to be elucidated.