Open AccessTranscription Factor Signatures May Predict the Prognosis and Status of the Immune Microenvironment of Primary Lower-Grade Gliomas
Author(s) -
Peidong Liu,
Ruojie Wu,
Jinhao Zhang,
Yiming Zhang,
Chen Zhang,
Lei Chen,
Shukun Yu,
Xuejun Yang
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s335399
Subject(s) - glioma , proportional hazards model , medicine , oncology , transcription factor , tumor microenvironment , gene , survival analysis , immune system , gene signature , disease , computational biology , bioinformatics , cancer research , cancer , immunology , biology , gene expression , genetics
Transcription factor (TF) in glioma, including proliferation, invasion/migration, and tumor microenvironment, has been receiving increasing attention. However, there are still no systematical analyses based on global TF. Herein, using global TF target gene sets, we comprehensively investigated their relationship with prognosis and potential biological effect in lower-grade glioma (LGG). We aimed to develop a less-biased prognostic model and provide new insight for personalized management of this disease.