Open AccessPan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker
Author(s) -
Chengwen Zhao,
Yonghui Liu,
Shaoqing Ju,
Xudong Wang
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s331752
Subject(s) - microsatellite instability , cancer research , immune system , medicine , cancer , methyltransferase , immune checkpoint , dna mismatch repair , gene , biology , immunotherapy , immunology , colorectal cancer , genetics , methylation , allele , microsatellite
Fat mass and obesity-associated protein (FTO) is a critical N6-methyladenosine (m6A) demethylase that participates in tumorigenesis and is associated with the prognosis of patients in some cancers. However, the key roles of FTO in pan-cancer are still largely obscure.