Open AccessDifferent Cutoff Values for Increased Nuchal Translucency in First-Trimester Screening to Predict Fetal Chromosomal Abnormalities
Author(s) -
Linjuan Su,
Xiaoqing Wu,
Na Lin,
Xiaorui Xie,
Meiying Cai,
Meiying Wang,
Lin Zheng,
Liangpu Xu
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s330960
Subject(s) - cutoff , medicine , receiver operating characteristic , trisomy , nuchal translucency , nuchal translucency measurement , predictive value , prenatal diagnosis , nuclear medicine , gynecology , fetus , obstetrics , pregnancy , genetics , biology , physics , quantum mechanics
Increased nuchal translucency (NT) is closely related to an increased risk of chromosomal abnormalities. However, the criterion of increased NT for invasive prenatal diagnosis remains controversial, as the cutoff values are inconsistent among countries. This study was conducted to compare the various cutoff values of increased NT and calculate the incidence of chromosomal abnormalities to determine the predictive ability of these cutoff values in conventional chromosome analysis.