Open AccessSystemic Profiling of KDM5 Subfamily Signature in Non-Small-Cell Lung Cancer
Author(s) -
Fang Hao
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s329733
Subject(s) - subfamily , immune system , epigenetics , lung cancer , cancer research , chromatin , biology , histone , gene , medicine , immunology , pathology , genetics
Despite improvements in diagnosis and treatment, lung cancer is one of the most lethal human diseases, with a dismal 5-year relative survival rate of only 5% for patients diagnosed with advanced metastatic disease. Accumulating evidence supports that epigenetic aberration of histone demethylase-KDM5 subfamily is linked to human pan-cancer. However, the detailed functions of KDM5 proteins in lung cancer, especially in non-small-cell lung cancer (NSCLC), remain poorly understand.