Open AccessUpregulation of THBS1 is Related to Immunity and Chemotherapy Resistance in Gastric Cancer
Author(s) -
Xiuyuan Zhang,
Tingting Huang,
Yiming Li,
Hong Qian
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s329208
Subject(s) - thrombospondin 1 , cancer research , immune system , medicine , downregulation and upregulation , carcinogenesis , tumor microenvironment , angiogenesis , cancer , immunology , biology , gene , biochemistry
Thrombospondin 1 ( THBS1 ) is an endogenous inhibitor of angiogenesis, but it also promotes tumor invasion, metastasis, and immune response in the tumor environment. Previous research has found that THBS1 is highly expressed in many tumors and has a negative correlation with tumor prognosis. However, research on the relationship between THBS1 and immune infiltration in GC is less well documented, and the objective of our study was to investigate the role of THBS1 expression in GC.