Open AccessThe Identification of Alternative Polyadenylation in Stomach Adenocarcinomas Using the Genotype-Tissue Expression Project and the Cancer Genome Atlas– Stomach Adenocarcinoma Profiles
Author(s) -
Jian Li,
Wen Chen,
Yi Cao,
Zhengrong Li
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s329064
Subject(s) - polyadenylation , untranslated region , gene , microrna , biology , genetics , messenger rna , cancer , computational biology , three prime untranslated region , genome , gene expression , genotype , bioinformatics , cancer research
Alternative polyadenylation (APA) is a common mechanism that is present in most human genes and determines the length of the messenger ribonucleic acid (mRNA) three prime untranslated region (3'-UTR), which can give rise to changes in mRNA stability and localization. However, little is known about the specific changes related to APA in stomach adenocarcinomas (STADs).