Open AccessOverexpression of IRF3 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
Author(s) -
Jun Wu,
Xuefeng Leng,
Zhengbo Pan,
Linfei Xu,
Haitao Zhang
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s328225
Subject(s) - clear cell renal cell carcinoma , irf3 , kegg , cancer research , medicine , transcription factor , cancer , carcinogenesis , biology , bioinformatics , gene , oncology , computational biology , renal cell carcinoma , gene expression , transcriptome , genetics
Growing findings have demonstrated that interferon regulatory transcription factor (IRF) family members are linked to the progression of various cancers. However, the roles of IRFs in clear cell renal cell carcinoma (ccRCC) remain undefined. Herein, we conducted a comprehensive analysis using the bioinformatics method to evaluate the expression patterns, clinical significance, and regulation of IRFs-related mechanisms in patients with ccRCC.