Open AccessPER1 as a Tumor Suppressor Attenuated in the Malignant Phenotypes of Breast Cancer Cells
Author(s) -
Yinfeng Liu,
Jun Hao,
Guanli Yuan,
Mengyu Wei,
Yuhui Bu,
Tingting Jin,
Li Ma
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s328184
Subject(s) - per1 , breast cancer , cancer research , cancer , medicine , oncology , phenotype , western blot , tumor suppressor gene , biology , carcinogenesis , clock , circadian rhythm , gene , genetics , circadian clock
Circadian clock genes play a crucial role in physiological and pathological processes, and their aberrant expressions were involved in various human cancers. The objective of this study was to investigate the expression level of Period circadian regulator 1 (PER1), an important circadian clock gene, and its biological roles in the development and progression of breast cancer.