Open AccessAnalysis of Ferroptosis-Related Gene Expression and Prognostic Factors of Renal Clear Cell Carcinoma Based on TCGA Database
Author(s) -
Sijia Ma,
Mingming Zhao,
Junfen Fan,
Mei-Ying Chang,
Zhiyu Pan,
Ziyan Zhang,
Shunxuan Xue,
Qi Li,
Yu Zhang
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s323511
Subject(s) - proportional hazards model , clear cell renal cell carcinoma , medicine , oncology , kegg , gene , database , renal cell carcinoma , bioinformatics , cancer research , gene expression , biology , transcriptome , genetics , computer science
Renal clear cell carcinoma (ccRCC) is a common tumor of the urinary system, most of which are primary malignant tumors with high metastatic rate and remaining incurable. Ferroptosis is a newly discovered form of iron-dependent programmed cell necrosis in recent years, which is inextricably linked to the occurrence and development of tumors progression. Due to the complexity of the interaction between genes in ccRCC, the research on the pathogenesis of ccRCC is still not remarkably accurate. Therefore, whether ferroptosis-related genes (FRGs) can play a role in predicting prognosis in ccRCC needs to be discussed.