Open AccessA Comparative Evaluation of an Automated Functional Assay for Von Willebrand Factor Activity in Type 1 Von Willebrand Disease
Author(s) -
ShiueWei Lai,
Ching-Yu Chang,
ShinNan Cheng,
Shu-Hsia Hu,
ChungYu Lai,
YeuChin Chen
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s321605
Subject(s) - medicine , von willebrand disease , ristocetin , von willebrand factor , coagulation , gastroenterology , platelet
von Willebrand factor ristocetin cofactor activity (VWF:RCo) is the standard functional assay used for von Willebrand disease (VWD) diagnosis. However, it has some drawbacks including being time consuming and labor intensive and having high inter-laboratory variability. The HemosIL VWF activity assay has the advantages of both high speed and automation. The purpose of this study was to prospectively compare these two functional assays for type 1 VWD detection.