Open AccessDefective Allele of the Neuronal Nitric Oxide Synthase Gene Increases Insulin Resistance During Acute Phase of Myocardial Infarction
Author(s) -
Otávio de Tolêdo Nóbrega,
Alessandra M. Campos-Staffico,
Elayne Kelen de Oliveira,
Daniel Munhoz,
Filipe A. Moura,
Luiz Sérgio Fernandes de Carvalho,
Alexandre Anderson de Sousa Munhoz Soares,
Ciro Martins Gomes,
Audrey Cecília Tonet Furioso,
Andrei C. Sposito
Publication year - 2021
Publication title -
international journal of general medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.722
H-Index - 36
ISSN - 1178-7074
DOI - 10.2147/ijgm.s313661
Subject(s) - medicine , insulin resistance , neuronal nitric oxide synthase , nitric oxide synthase , nitric oxide , myocardial infarction , gene , allele , cardiology , insulin , pharmacology , genetics , biology
Glycemic disorders are strong predictors of mortality in ST-elevation myocardial infarction (STEMI) patients, and disruption in nitric oxide (NO) production is associated with insulin-resistant states. We evaluated whether a defective allele of the neuronal nitric oxide synthase (nNOS) gene ( NOS1 ) might influence insulin response and blood-glucose balance during the acute phase of STEMI and if post-infarction total plasma-NO levels and vasodilation scores varied across nNOS genotypes.